Micky van de Ven Brace Halts The Toffees' Run at New Stadium
Micky van de Ven became the initial defender to net twice in a Premier League game for Spurs since Jan Vertonghen in March 2013.
At a glance
The Spurs defender heads into the net two times in first half
Everton's Jake O'Brien has goal ruled after VAR review
Pape Matar Sarr nets third in dying moments
The defeat is the Merseyside club's first at their new ground
Micky van de Ven scored on two occasions as Tottenham prolonged their unbeaten run on the road in the Premier League and delivered the Toffees their first defeat at Hill Dickinson Stadium.
The Toffees were unbeaten in their last five matches at their recently opened stadium at the dockside location, having departed their historic home behind after 133 years at the end of the previous campaign.
But Tottenham's leader Van de Ven pounced on two occasions from corners in the first half to place their impressive record at jeopardy, and they were unable to mount a comeback before Pape Matar Sarr - set up by ex-Everton forward the Brazilian - nodded in a final goal to seal the victory.
The Everton defender thought he had levelled the tally five minutes after the defender's opener, directing a powerful header past Guglielmo Vicario from an set-piece.
Beto, in the meantime, failed to convert a handful of opportunities, while the Italian goalkeeper made a series of excellent saves to ensure the London club went five matches on the road without defeat in the English top flight.
But the video assistant referee intervened, instructing Craig Pawson to check the goal on the pitchside monitor and the referee ruled that Jack Grealish and the attacker were in an illegal position and had impeded with the Tottenham goalkeeper.
The win moves the manager's team up to third in the Premier League, five points off local foes and table-toppers the Gunners.
Everton stay 14th and are half a dozen points clear of the drop zone.
Spurs breakdown: Van de Ven fulfils duties at both ends of pitch
After a drab weekday display in the Champions League against the French side, where they mustered a only two shots on goal, the manager opted for Randal Kolo Muani up front instead of former Toffees player the Brazilian.
The summer signing was unable to influence the game before being substituted for the substitute after 60 minutes on the field, but it turns out he wasn't needed in the end.
Centre-back Van de Ven transformed into an offensive threat to be reckoned with.
Spurs' first goal came from a well-worked corner routine, with the midfielder directing the ball toward the face of goal for an free Van de Ven to score.
And the captain - stepping up as skipper in Cristian Romero's absence - notched his next goal in first-half stoppage time as he outjumped Jordan Pickford to head home.
The Dutchman was equally impressive in defensive duties, combining effectively with Kevin Danso as the duo dealt superbly with the 34 crosses thrown their way by Everton.
Everton analysis: Everton lacking striker's instinct
The club's new home had been a fortress, but it appears the novelty may have faded slightly and fans headed to the gates after the midfielder's third for Tottenham.
The break in Everton's unbeaten home run won't be a massive concern for the manager, but their attacking woes are.
The forward and the other striker - the Everton's pair of established centre-forwards - had scored just one league goal combined before Sunday's outing.
And they were unable to add to that poor tally on a damp and dreary night on Merseyside.
Beto's performance was epitomized when he opted to overhead kick a clear chance from close range, despite having room and time to reposition for a more conventional attempt that would have challenged Vicario.
Barry, too, failed to influence the game after coming on for Beto in the 65th minute.
It was not for a shortage of opportunity. The majority of Everton's offensive moves came through the winger and Ndiaye, who relentlessly whipped dangerous balls into the Spurs box.
What next for these two sides?
Everton: Moyes' men head to the Stadium of Light in the top flight on Monday, 3 November at 20:00 GMT.
Spurs: Spurs go to St James' Park on Wednesday, 29 October for their next round Carabao Cup match against the Magpies.